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Norepinephrine Depletion in Idiopathic Orthostatic Hypotension

HERMES A. KONTOS, M.D., Ph.D., F.A.C.P.; DAVID W. RICHARDSON, M.D., F.A.C.P.; JOHN E. NORVELL, Ph.D. Five patients with idiopathic orthostatic hypotension and defective vasoconstrictor responses to ... read more

First Neurogenic Orthostatic Hypotension Drug OK’d in Two Decades

Norepinephrine increases blood pressure by inducing peripheral arterial and venous vasoconstriction. The exact mechanism of action in the treatment of neurogenic orthostatic hypotension is unknown. ... read more

What causes postural orthostatic tachycardia syndrome (POTS)?

A norepinephrine ... and Vitamin B12 Deficiency in Adolescents. Pediatrics. 2014 Jan. 133(1):e138-42. [Medline]. Sithinamsuwan P, Orrawanhanothai P, Thithum K, Udommongkol C, Chairangsaris P, ... read more

Lundbeck Announces Availability of NORTHERA™ (droxidopa) Capsules in the U.S. for Symptomatic Neurogenic Orthostatic Hypotension

NORTHERA, a norepinephrine ... symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (Parkinson’s disease, multiple system atrophy, and pure autonomic failure), ... read more

PRESS RELEASE: European Commission Grants Chelsea Therapeutics Two Orphan Medicinal Product Designations for Droxidopa

About Droxidopa and Symptomatic Neurogenic Orthostatic Hypotension ... a deficient release of norepinephrine, the neurotransmitter used by sympathetic autonomic nerves to send signals to the blood ... read more

Neurogenic Orthostatic Hypotension: Pathophysiology and Diagnosis

Although orthostatic hypotension in elderly patients is common ... Monoamine oxidase inhibitors may cause OH by depleting norepinephrine. 12 OH is common in elderly patients and increases with age. In ... read more

Orthostatic Hypotension Drug Updated with New Warnings

Northera, a norepinephrine prodrug, is indicated to treat symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure (Parkinson’s disease, multiple system atrophy, and pure ... read more

The syndromes of orthostatic Intolerance

Orthostatic intolerance syndromes refer to symptoms in which the upright position (most often the movement from sitting or lying to an upright position) causes symptomatic arterial hypotension ... to ... read more

European Commission Grants Chelsea Therapeutics Two Orphan Medicinal Product Designations for Droxidopa

About Droxidopa and Symptomatic Neurogenic Orthostatic Hypotension ... a deficient release of norepinephrine, the neurotransmitter used by sympathetic autonomic nerves to send signals to the blood ... read more

Chelsea Therapeutics Announces FDA Accelerated Approval of NORTHERA™ (Droxidopa)for the Treatment of Symptomatic NOH

Symptomatic NOH is an autonomic nervous system disorder caused by failure to produce and or release adequate amounts of norepinephrine upon standing. Norepinephrine deficiency results ... on the ... read more

FDA Sends Hypotension Drug Droxidopa for More Study

March 30, 2012 — The US Food and Drug Administration (FDA) would like to see more evidence for droxidopa in the treatment of neurogenic orthostatic ... norepinephrine as it passes through the ... read more