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Future Therapeutic Options for Celiac Disease

and blocking the binding of gluten peptides to the HLA-DQ2 or HLA-DQ8 molecules. Other possible treatments include cytokine therapy, and selective adhesion molecule inhibitors that interfere with ... read more

Diagnostic Dilemmas in Celiac Disease

[47] In individuals positive for HLA-DQ2 or -DQ8, an initial gluten challenge comprising 3 g dietary gluten (or two slices bread) per day for 2 weeks may be initiated. [52] Patients with atypical ... read more

Is There a Gluten Intolerance Test?

These tests include: HLA-DQ2 and HLA-DQ8 tests. These tests detect specific gene mutations (HLA-DQ2 and HLA-DQ8), that occur in 95% and 5% of people with celiac disease, respectively. If the ... read more

Living with Celiac Disease: A Guide to Gluten-Free Living

The presence of specific human leukocyte antigen (HLA) genes, particularly the HLA-DQ2 and HLA-DQ8 genes, is the main genetic component linked to this disease. The HLA-DQ2 or HLA-DQ8 gene is ... read more

Randomized Feeding Intervention in Infants at High Risk for Celiac Disease

We performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 and had at least one first ... read more

Celiac Disease

76,77 Therapies that interfere with the immune response — by blocking the binding of deaminated gliadin to HLA-DQ2 or HLA-DQ8, for example, or by blocking the action of tissue transglutaminase ... read more

The Top 25 Health Sciences Articles of 2023

Here the authors generate and characterize a broadly neutralizing antibody recognizing more than 25 gluten peptide:HLA-DQ2.5 complexes, with structural analyses implicating its mode of interaction ... read more
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