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Thalidomide Downregulates Angiogenic Genes in Bone Marrow Endothelial Cells of Patients With Active Multiple Myeloma

Patients and Methods The expression of key angiogenic genes was studied in bone marrow endothelial cells ... cell line, but upregulates them or is ineffective in nonactive MMECs, MG(u)ECs, NHL-ECs, an... read more

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

Both LPS and the FBG domain of tenascin-C stimulate p38, c-Jun N-terminal kinase, and nuclear factor κB signaling ... anti-pp38α antibody (#9211, Cell Signaling Technology) diluted in blocking solutio... read more

The role of oxygen availability in embryonic development and stem cell function

The best genetic evidence is provided by animals that lack various subunits of the hypoxia inducible factor (HIF) heterodimeric transcription factors. Recently, stem and progenitor cell ... cells, inc... read more

Physiologic Changes of the Cornea with Contact Lens Wear

This article reviews the corneal changes resulting from the ... to primitive vascular mesenchyme. Vasostimulatory factors initiate new growth by a direct effect on the endothelial vascular cells and d... read more

Potential Role of Selective COX-2 Inhibitors in Cancer Management

Howe LR, Subbaramaiah K, Chung WJ, et al: Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res 59:1572-1577, 1999. 8. Huang M, Sharma S, Mao J... read more

Newborn Screening Fact Sheets

Newborn screening fact sheets were last revised ... screening as a public health system; factors contributing to the need for review of the newborn screening system; informed consent; tandem mass spec... read more

Dr. Paul Sternberg

Dr. Paul Sternberg is an ophthalmologist in Nashville, Tennessee and is affiliated with multiple hospitals in the area, including Tennessee Valley Healthcare System-Nashville and Vanderbilt University ... read more

The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

Departments of Cell and Tissue ... come to appreciate that cells regulate their TGF-β responsiveness by controlling the functional receptor abundance at the cell surface. Activation of the Erk or p38 ... read more

Ocular Manifestations of Donohue’s Syndrome

No conjunctival, scleral, or corneal ... and bovine lens epithelium provide an opportunity for studying the biochemical regulation of cell growth and differentiation. The precise regulatory relationsh... read more

Building drug delivery into tissue engineering design

Growth factors are ... three-dimensional cell-culture patterns that are composed of many types of cell can be formed 59. These three-dimensional patterning techniques have been used to place cancer ce... read more

Human limbal biopsy–derived stromal stem cells prevent corneal scarring

1 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. 2 L V Prasad Eye Institute, Hyderabad 500034, India. 3 Department of Molecular Pharmacology and P... read more

Forty-Year Journey of Angiogenesis Translational Research

1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden. 2 Department of Medicine and Health Sciences, Linköping University, 581 83 Linköping, Sweden. 3 De... read more