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Formation of three-dimensional tubular endothelial cell networks under defined serum-free cell culture conditions in human collagen hydrogels

Implementation of tubular endothelial ... cells, and infiltration with dextran (Fig. 4) compared to Matrigel/rCOL constructs cultivated either in EGM-2 or SFM. Apparently, the amount of growth factors ... read more

Biologic Therapy: Hematopoietic Growth Factors, Retinoids, and Monoclonal Antibodies

The major cellular sources of the growth factors are monocytes, macrophages, T lymphocytes, endothelial ... cells of the kidneys and the Kupffer cells of the liver. Most growth factors stimulate more ... read more

Thalidomide Downregulates Angiogenic Genes in Bone Marrow Endothelial Cells of Patients With Active Multiple Myeloma

Patients and Methods The expression of key angiogenic genes was studied in bone marrow endothelial cells ... cell line, but upregulates them or is ineffective in nonactive MMECs, MG(u)ECs, NHL-ECs, ... read more

Cornea and Ocular Surface Disease: Application of Cutting-Edge Optometric Research

It is well established that growth factors ... in vivo corneal endothelial pump. Invest Ophthalmol Vis Sci 2012; 53: 2020–9. 40. Nguyen TT, Bonanno JA. Bicarbonate, NBCe1, NHE, and carbonic anhydrase ... read more

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

Both LPS and the FBG domain of tenascin-C stimulate p38, c-Jun N-terminal kinase, and nuclear factor κB signaling ... anti-pp38α antibody (#9211, Cell Signaling Technology) diluted in blocking ... read more

Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways

Cells were blocked with 1% bovine ... growth factor. Herein, we demonstrated that CXCL1 stimulates human endothelial cells and increases rates of angiogenesis. Blockade of CXCL1 with a neutralizing ... read more

Acidic Fibroblast Growth Factor Induces an Antifibrogenic Phenotype in Human Lung Fibroblasts

Acidic fibroblast growth factor (FGF-1), a prototype member of the heparin-binding growth factor family, influences proliferation, differentiation, and protein synthesis ... media of cell lines under ... read more

Regenerative nanomedicine: current perspectives and future directions

Since the cell ... like cells (MG63) have good growth and proliferation potential with the upregulation of collagen I and alkaline phosphatase. 29 A recent study comparing the effects of nanomaterials ... read more

Human limbal biopsy–derived stromal stem cells prevent corneal scarring

1 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. 2 L V Prasad Eye Institute, Hyderabad 500034, India. 3 Department of Molecular Pharmacology and ... read more

Stress-Activated Protein Kinases Mediate Cell Migration in Human Airway Epithelial Cells

Primary cells were maintained in defined medium for the 24-h imaging period after wound generation to prevent any confounding effects from withdrawal of growth factors. Linear wounds of ∼ 1–2 mm width ... read more

The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

Departments of Cell and Tissue ... come to appreciate that cells regulate their TGF-β responsiveness by controlling the functional receptor abundance at the cell surface. Activation of the Erk or p38 ... read more

Forty-Year Journey of Angiogenesis Translational Research

1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden. 2 Department of Medicine and Health Sciences, Linköping University, 581 83 Linköping, Sweden. 3 ... read more