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Auris Medical's (EARS) CEO Thomas Meyer on Q1 2018 Results - Earnings Call Transcript

Betahistine increases inner ear and cerebral blood flow, histamine turnover and histamine release in the brain, enhances the release of acetylcholine, dopamine and norepinephrine ... that is 7% or mor... read more

Eli Lilly’s Alzheimer’s Antibody Does Not Work

After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III tri... read more

Electroconvulsive Therapy Alters Dopamine Signaling in the Striatum of Non-human Primates

PET scans were performed prior to the onset of ECT treatments and at 24–48 h, 8–10 days, and 6 weeks after the final ECT treatment. Early increases ... allows the study of brain function and pharmacol... read more

Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice

Renoir T, Chevarin C, Lanfumey-Mongredien L, Hannan AJ. Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice. PLOS Currents Huntington Disease. 2011 ... read more

MR Imaging–Detectable Metabolic Alterations in Attention Deficit/Hyperactivity Disorder: From Preclinical to Clinical Studies

Ten subjects with ADHD underwent MR spectroscopy before and after a 6- to 8-week methylphenidate oral treatment ... turnover. 64 Choline is the precursor of acetyl-choline and influences the neural co... read more

The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon Superfamily

The pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily includes nine hormones in humans that are related by structure, distribution (especially the brain and gut), functio... read more

Possible mechanisms of central nervous system fatigue during exercise

Much less effort has been focused on CNS fatigue even though it has been documented for over a century that “psychological factors” can affect exercise performance and that a dysfunction at any step i... read more

Auris Medical Holding AG (EARS)

Zug, Switzerland, January 23, 2019 - Auris Medical Holding AG (NASDAQ ... switching over to placebo and vice versa. Treatment with betahistine overall improved the percentage of correct memories (p<0. ... read more

Translating Glutamate: From Pathophysiology to Treatment

Here, we review a recent Institute of Medicine–sponsored meeting, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development. Th... read more

Pancreatic regulation of glucose homeostasis

This is accomplished by a highly sophisticated network of various hormones and neuropeptides released mainly from the brain, pancreas, liver, intestine as well as adipose and muscle tissue. Within thi... read more

GABAergic modulation of noradrenaline release caused by blood pressure changes in the rat median preoptic area

Either bicuculline or phaclofen administered together with the metaraminol further enhanced the metaraminol-induced MAP and NA release in the MnPO area. The degree of increases in the both MAP of the ... read more

Molecular Imaging for Depressive Disorders

Molecular imaging techniques such as MR spectroscopy and PET have been used to explore the molecular pathophysiology of depression and assess treatment ... cortical brain regions. Early hypotheses inv... read more