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Auris Medical's (EARS) CEO Thomas Meyer on Q1 2018 Results - Earnings Call Transcript

Betahistine increases inner ear and cerebral blood flow, histamine turnover and histamine release in the brain, enhances the release of acetylcholine, dopamine and norepinephrine ... that is 7% or mor... read more

Norepinephrine Transporter Function and Autonomic Control of Metabolism

At rest, energy expenditure and substrate oxidation rates did not differ between reboxetine and placebo treatment. At 1 μg/min isoproterenol ... we determined the effect of this manipulation of norepi... read more

New study explains how stress can boost immune system

He and colleagues had previously shown that a similar immune-cell redistribution in patients experiencing the short-term stress of surgery predicts enhanced ... treatment produced no such effect. The ... read more

Eli Lilly’s Alzheimer’s Antibody Does Not Work

After years of work and untold amounts of money, Eli Lilly’s Alzheimer’s antibody, solanezumab, does not work. It does not help Alzheimer’s patients. No matter how many times you run the Phase III tri... read more

Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice

Renoir T, Chevarin C, Lanfumey-Mongredien L, Hannan AJ. Effect of enhanced voluntary physical exercise on brain levels of monoamines in Huntington disease mice. PLOS Currents Huntington Disease. 2011 ... read more

Mazindol Treatment of Negative Symptoms

These considerations suggest a therapeutic hypothesis, that enhanced ... Mazindol is a potent antagonist of both DA and NE transporters (Heikkila et al. 1977) and is selected for testing on the basis ... read more

Molecular Imaging for Depressive Disorders

Molecular imaging techniques such as MR spectroscopy and PET have been used to explore the molecular pathophysiology of depression and assess treatment ... cortical brain regions. Early hypotheses inv... read more

Brain Corticosteroid Receptor Balance in Health and Disease

Access of corticosteroids to brain receptors ... condition of enhanced vulnerability to disease. In this review, we have described the function of MR and GR in hippocampal neurons. The balance in acti... read more

Possible mechanisms of central nervous system fatigue during exercise

The most prominent one involves an increase in 5-HT activity in various brain regions. Good evidence suggests that ... whether the force exerted voluntarily by a subject can be enhanced by a single or ... read more

Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR

Correspondence: Dr RA Ophoff, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA. E-mail: rophoff@mednet.ucla.edu ... read more

Electroacupuncture Enhances the Antiallodynic and Antihyperalgesic Effects of Milnacipran in Neuropathic Rats

BACKGROUND: Milnacipran, a selective serotonin/norepinephrine-reuptake inhibitor ... effects than those obtained from EA or milnacipran alone at 1, 2, and 4 hours after treatment, indicating an additi... read more